Co-Director of the Johns Hopkins Myositis Center
Associate Professor of Neurology and Medicine
Dr. Mammen sees patients with diseases affecting muscle and has a special interest in autoimmune myositis and statin-associated myopathies.
His research focuses on statin-triggered muscle disease, muscle regeneration in myositis, as well as the link between myositis and cancer.
Dr. Mammen is the recipient of the 2007 Passano Physician Scientist Award and the 2012 Sir William Osler Young Investigator Award.
- MD: Johns Hopkins University, School of Medicine
- PhD: Johns Hopkins University, School of Medicine
- Internship: Johns Hopkins Hospital
- Neurology Residency: Johns Hopkins Hospital
- Neuromuscular Fellowship: Johns Hopkins Hospital
Publications: Peer-reviewed Original Science Research
1. Podlisney M, Mammen A, Schlossmacher M, Palmer M, Younkin S, Selkoe D. Detection of soluble forms of the beta-amyloid precursor protein in human plasma. Biochemical and Biophysical Research Communications. 1990; 167: 1094-1101.
2. Hirsch D, Steiner J, Dawson T, Mammen A, Hayek E, Snyder S. Neurotransmitter release regulated by nitric oxide in PC-12 cells and brain synaptosomes. Current Biology. 1993; 3: 749-754.
3. Von Koch C, Lahiri D, Mammen A, Copeland N, Gilbert D, Jenkins N, Sisodia S. The mouse APLP2 gene: chromosomal localization and promotor characterization. The Journal of Biological Chemistry. 1995; 270: 25475-25480.
4. Lau L-F, Mammen A, Ehlers M, Kindler S, Chung W, Garner C, Huganir R. Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102. The Journal of Biological Chemistry. 1996; 271: 21622-21628.
5. Roche K, O’Brien R, Mammen A, Bernhardt J, Huganir R. Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. Neuron. 1996; 16: 1179-1188.
6. Mammen A, Kameyama K, Roche K, Huganir R. Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II. The Journal of Biological Chemistry. 1997; 272: 32528-32533.
7. O’Brien R, Mammen A, Blackshaw S, Ehlers M, Rothstein J, Huganir R. The development of excitatory synapses in cultured spinal cord neurons. The Journal of Neuroscience. 1997; 17: 7339-7350.
8. Mammen A, Huganir R, O’Brien R. Redistribution and stabilization of cell surface glutamate receptors during synapse formation. The Journal of Neuroscience. 1997; 17: 7351-7358.
9. Mammen A*, Casciola-Rosen L, Hall J, Christopher-Stine L, Corse A, and Rosen A. Expression of the dermatomyositis autoantigen Mi-2 in regenerating muscle. Arthritis and Rheumatism. 2009; 60: 3784-3793. (*Corresponding author)
10. Valiyil R, Casciola-Rosen L, Hong G, Mammen A, and Christopher-Stine L. Rituximab Therapy for Myopathy Associated with Anti-Signal Recognition Particle Antibodies: A Case Series. Arthritis Care and Research. 2010; 62: 1328-34.
11. Christopher-Stine L, Casciola-Rosen L, Hong G, Chung T, Corse A, and Mammen A*. A novel autoantibody recognizing 200 and100 kDa proteins is associated with an immune-mediated necrotizing myopathy. Arthritis and Rheumatism. 2010; 62: 2757-66. (*Corresponding author)
12. Mammen A*, Chung T, Christopher-Stine L, Rosen P, Rosen A, Casciola-Rosen L. Autoantibodies against 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (HMGCR) in Patients with Statin-Associated Autoimmune Myopathy. Arthritis and Rheumatism. 2011; 63: 713-21. (*Corresponding author)
13. Moghekar A, Rao S, Li M, Ruben D, Mammen A, Tang X, and O’Brien RJ. Large quantities of Ab peptide are constitutively released during amyloid precursor protein metabolism in vivo and vitro. The Journal of Biological Chemistry. 2011; 286:15989-97.
14. Williams K, Ostrow L, Loeb D, Chung T, Cohn R, Corse A, Mammen A. Immunohistochemistry of affected tissue may guide cGVHD treatment decisions. Bone Marrow Transplant. 2011: 47(5):731-3.
15. Mammen A, Mahoney J, St. Germain A, Badders N, Taylor J, Rosen A, Spinette S. A Novel Conserved Isoform of the Ubiquitin Ligase UFD2a/UBE4B is Expressed Exclusively in Mature Striated Muscle Cells. PLoS One. 2011;6(12):e28861.
16. Mammen A*, Pak K, Williams E, Brisson D, Coresh J, Selvin E, Gaudet D. Anti-HMG-CoA reductase antibodies are rare in statin users, including those with self-limited musculoskeletal side-effects. Arthritis Care and Research. 2012: 64(2):269-72. (*Corresponding author)
17. Mammen A*, Gaudet D, Brisson D, Christopher-Stine L, Leffell S, Zachary A. Increased Frequency of DRB1*11:01 in Anti-HMG-CoA Reductase-Associated Autoimmune Myopathy. Arthritis Care and Research, 2012: 64(8):1233-7. (*Corresponding author)
18. Ostrow L, Corse A, Morrison B, Huff C, Carrino J, Hoke A, Mammen A*. Expanding the Spectrum of Monoclonal Light Chain Deposition Disease in Muscle. Muscle and Nerve. 2012; 45:755-61. (*Corresponding author)
19. Casciola-Rosen L, Hall J, Mammen A, Christopher-Stine L, Rosen A. Isolated elevation of aldolase in the serum of myositis patients: a potential biomarker of damaged early regenerating muscle cells. Clinical and Experimental Rheumatology, 2012 May 30. [Epub ahead of print]
20. Werner J, Christopher-Stine L., Ghazarian SR, Pak K, Kus JE, Lloyd TE, and Mammen A.* Antibody Levels Correlate with Creatine Kinase Levels and Strength in Anti-HMG-CoA Reductase-Associated Autoimmune Myopathy. Arthritis and Rheumatism. 2012. [Epub ahead of print]. PMID:22933019 (*Corresponding author)
21. Subhawong T, Wang X, Barker P, Machado A, Christopher-Stine L, Carrino J, Mammen A,and Fayad L. 1H Magnetic Resonance Spectroscopy Findings in Idiopathic Inflammatory Myopathies at 3 Tesla: Feasibility and First Results. Investigative Radiology (in press).
Publications: Review Articles (Invited and Peer-Reviewed)
1. Selkoe D, Podlisny MB, Gronbeck A, Mammen A, Kosik KS. Molecular relation of amyloid filaments and paired helical filaments in Alzheimer’s disease. Advances in Neurology. 1990; 51:171-179.
2. Ehlers M, Mammen A, Lau L-F, Huganir R. Synaptic targeting of glutamate receptors. Current Opinion in Cell Biology. 1996; 8: 484-489.
3. Mammen A, Kamboj S, Huganir R. Protein phosphorylation of ligand-gated ion channels. Methods in Enzymology. 1999; 294: 353-370.
4. Mammen A. Dermatomyositis and Polymyositis: Clinical Presentation, Autoantibodies, and Pathogenesis. Annals of the New York Academy of Sciences. 2009; 1184:134-153 (2009).
5. Mammen A and Amato AA. Statin Myopathy: A review of recent progress. Current Opinion in Rheumatology. 2010; 22: 644-650.
6. Mammen A. The Autoimmune Myopathies: Autoantibodies, Distinct Clinical Phenotypes, and Pathogenesis. Nature Reviews Neurology. 2011; 7:343-354.
7. Del Grande F, Carrino J, Del Grande M, Mammen A, and Christopher-Stine, L. Magnetic Resonance Imaging of Inflammatory Myopathies. Topics in Magnetic Resonance Imaging. 2011; 22: 39-43
8. Casciola-Rosen L and Mammen A. Myositis Autoantibodies. Current Opinion in Rheumatology. 2012; Epub ahead of print. PMID: 22955022